Two handy words with only one differing letter are AIRIEST and AERIEST . Each has one anagram. AERIEST (Anagram = SERIATE) Meaning: Aery is a poetic variant of 'airy', also meaning 'lofty, insubstantial or visionary'. 'Seriate' means 'arranged or occurring in a series or in rows'. AIRIEST (Anagram = IRISATE) Meaning: Airy means 'open to the air' and 'irisate' means 'to make iridescent' (like a rainbow).
Tips for playing Scrabble using the SOWPODS English and American dictionaries